Week 21 of the CFL season kicks off with the Winnipeg Blue Bombers (13-4) on the road against the Calgary Stampeders (6-11) on Friday. Kickoff is  at 9 p.m. ET at McMahon Stadium. Below, we analyze FanDuel Sportsbook’s lines around the Blue Bombers vs. Stampeders odds, and make our expert CFL picks and predictions.

Winnipeg has won 3 straight games and is coming off a 45-25 home win as 10-point favorites against Edmonton as the Over (50) cashed.

Calgary beat BC on the road last week 41-16 as 7-point underdogs with the Over (48.5) also cashing in. The Stamps have won 2 in a row after snapping their 3-game skid.

Winnipeg is 2-0 against Calgary this season.

Blue Bombers at Stampeders odds

Odds provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:58 a.m. ET.

  • Moneyline (ML): Blue Bombers -135 (bet $135 to win $100) | Stampeders +115 (bet $100 to win $115)
  • Against the spread (ATS): Blue Bombers -2.5 (-110) | Stampeders +2.5 (-110)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+

Blue Bombers at Stampeders key injuries

Blue Bombers

  • DB Brandon Alexander (knee) out
  • QB Zach Collaros (non-injury related) questionable
  • WR Nic Demski (ankle) out
  • LB Shayne Gauthier (hip) questionable
  • OL Jemarcus Hadrick (hip) questionable
  • DB Demario Houston (knee) questionable
  • WR Dalton Shoen (ankle) out

Stampeders

  • DB Branden Dozier (calf) out
  • DL Terrell McClain (ankle) out
  • DB Brad Muhammad (hand) out

Blue Bombers at Stampeders picks and predictions

Prediction

Blue Bombers 28, Stampeders 20

Moneyline

Winnipeg is already 2-0 against Calgary this season with 24-11 home win and a 19-18 win in Calgary.

The Blue Bombers only have 2 losses in their last 10 games. The Stamps have won 2 in a row, but lost 6 of 7 prior to that.

Winnipeg has scored 30 or more points in 3 straight games and in 6 of their last 7.

Betting the Blue Bombers on the moneyline isn’t bad at -135 but with only a 2.5-point spread at -110, that is the better play.

PASS.

Against the spread

Winnipeg is 10-7 ATS this season, while Calgary is 9-8 ATS.

Only the Blue Bombers’ road win over Calgary was by less than 8 points while  4 of the Stamps’ last 6 losses have been by at least 3 points.

BET BLUE BOMBERS -2.5 (-110).

Over/Under

The Over has hit in 12 of Winnipeg’s 17 games this season. The Over is 7-0 in its last 7 games and 9-1 in its last 10.

BET OVER 46.5 (-110). 

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and us on Facebook.

Access NFL coverage:

SportsbookWire | BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire